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Endocrine - Adrenal Insufficiency

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A prospective multicenter study of adrenal function in critically ill children.
Menon K, Ward RE, Lawson ML, Gaboury I, Hutchison JS, H├ębert PC; Canadian Critical Care Trials Group.
Am J Respir Crit Care Med. 2010 Jul 15;182(2):246-51.

Rationale for inclusion: PEDIATRICS: Prospective observational study - prevalence 30.2% in peds ICU patients

Citations - 78 (as of July 2017)

Adrenal suppression following a single dose of etomidate for rapid sequence induction: a prospective randomized study.
Hildreth AN, Mejia VA, Maxwell RA, Smith PW, Dart BW, Barker DE.
J Trauma. 2008 Sep;65(3):573-9.

Rationale for inclusion: Single dose Etomidate associated with adrenal inhibition, ICU stay, and vent days in trauma patients.

Citations - 162 (as of July 2017)

Recommendations for the diagnosis and management of corticosteroid insufficiency in critically ill adult patients: consensus statements from an international task force by the American College of Critical Care Medicine.
Marik PE, Pastores SM, Annane D, Meduri GU, Sprung CL, Arlt W, Keh D, Briegel J, Beishuizen A, Dimopoulou I, Tsagarakis S, Singer M, Chrousos GP, Zaloga G, Bokhari F, Vogeser M; American College of Critical Care Medicine.
Crit Care Med. 2008 Jun;36(6):1937-49.

Rationale for inclusion: A concensus statement on the diagnosis and management of adrenal insufficiency.

Citations - 776 (as of July 2017)

Duration of adrenal inhibition following a single dose of etomidate in critically ill patients.
Vinclair M, Broux C, Faure P, Brun J, Genty C, Jacquot C, Chabre O, Payen JF.
Intensive Care Med. 2008 Apr;34(4):714-9.

Rationale for inclusion: Single dose Etomidate associated with adrenal inhibition for 48 hours.

Citations - 167 (as of July 2017)

Relative adrenal insufficiency: an identifiable entity in nonseptic critically ill patients?
Clin Endocrinol (Oxf). 2007 May;66(5):732-9. Epub 2007 Mar 23.
de Jong MF, Beishuizen A, Spijkstra JJ, Girbes AR, Groeneveld AB.

Rationale for inclusion: Steroid treatment did not change outcome in relative adrenal insufficiency in nonseptic ICU patients.

Citations - 12 (as of July 2017)

Adrenal function in sepsis: the retrospective Corticus cohort study.
Lipiner-Friedman D, Sprung CL, Laterre PF, Weiss Y, Goodman SV, Vogeser M, Briegel J, Keh D, Singer M, Moreno R, Bellissant E, Annane D; Corticus Study Group.
Crit Care Med. 2007 Apr;35(4):1012-8.

Rationale for inclusion: The classic CORTICUS Study: baseline cortisol less than 15 or deltamax <9 had higher likelihood of dying.

Citations - 219 (as of July 2017)

A single adrenocorticotropic hormone stimulation test does not reveal adrenal insufficiency in septic shock.
Loisa P, Uusaro A, Ruokonen E.
Anesth Analg. 2005 Dec;101(6):1792-8.

Rationale for inclusion: Results of ACTH stim test are not reproducible in patients with septic shock

Citations - 71 (as of  July 2017)

Adrenal insufficiency during septic shock.
Marik PE, Zaloga GP.
Crit Care Med. 2003 Jan;31(1):141-5.

Rationale for inclusion: Cortisol < 25 for diagnosis of adrenal insufficiency in septic shock.

Citations - 404 (as of July 2017)

Patterns of corticosteroid-binding globulin and the free cortisol index during septic shock and multitrauma.
Beishuizen A, Thijs LG, Vermes I.
Intensive Care Med. 2001 Oct;27(10):1584-91.

Rationale for inclusion: Decrease then normalization of binding globulin in sepsis and multitrauma patients.

Citations - 255 (as of July 2017)

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