Neuro - Agitation
- Dexmedetomidine reduces the risk of delirium, agitation and confusion in critically Ill patients: a meta-analysis of randomized controlled trials.
- Pasin L, Landoni G, Nardelli P, Belletti A, Di Prima AL, Taddeo D, Isella F, Zangrillo A.
- J Cardiothorac Vasc Anesth. 2014 Dec;28(6):1459-66.
Rationale for inclusion: This is one of many (but a more definitive) articles on value of dexmedetomidine use in the severely aggitated.
Citations - 46 (as of July 2017)
- Implementing the awakening and breathing coordination, delirium monitoring/management, and early exercise/mobility bundle into everyday care: opportunities, challenges, and lessons learned for implementing the ICU Pain, Agitation, and Delirium Guidelines.
- Balas MC, Burke WJ, Gannon D, Cohen MZ, Colburn L, Bevil C, Franz D, Olsen KM, Ely EW, Vasilevskis EE.
- Crit Care Med. 2013 Sep;41(9 Suppl 1):S116-27.
Rationale for inclusion: Important follow up study of the "wake up and breath" campaign to show efficacy.
Citations - 82 (as of July 2017)
- The Richmond Agitation-Sedation Scale: validity and reliability in adult intensive care unit patients.
- Sessler CN, Gosnell MS, Grap MJ, Brophy GM, O'Neal PV, Keane KA, Tesoro EP, Elswick RK.
- Am J Respir Crit Care Med. 2002 Nov 15;166(10):1338-44.
Rationale for inclusion: This is the original paper describing the validity of RASS which is still the most used method of sedation/agitation scoring.
Citations - 1633 (as of July 2017)
- Prolongation of the corrected QT and torsades de pointes cardiac arrhythmia associated with intravenous haloperidol in the medically ill.
- Metzger E, Friedman R.
- J Clin Psychopharmacol. 1993 Apr;13(2):128-32.
Rationale for inclusion: This article is responsible for the current practice of QT tracking with the use of Haldol and other neuroleptics such as Seroquel.
Citations - 171 (as of July 2017)