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Spinal Cord Injury

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Early versus delayed decompression for traumatic cervical spinal cord injury: results of the Surgical Timing in Acute Spinal Cord Injury Study (STASCIS).
Fehlings MG, Vaccaro A, Wilson JR, Singh A, W Cadotte D, Harrop JS, Aarabi B, Shaffrey C, Dvorak M, Fisher C, Arnold P, Massicotte EM, Lewis S, Rampersaud R.
PLoS One. 2012;7(2):e32037.

Rationale for inclusion: A prospective observational study of patients who underwent decompression of the cervical spinal cord before or after 24hrs revealed the early surgery group were nearly 3x as likely to achieve a 2 grade ASIA impairment scale improvement at 6 months.

Citations - 360 (as of July 2017)

A systematic review of the evidence supporting a role for vasopressor support in acute SCI.
Ploumis A, Yadlapalli N, Fehlings MG, Kwon BK, Vaccaro AR.
Spinal Cord. 2010 May;48(5):356-62.

Rationale for inclusion: A systematic review of a topic with limited evidentiary support.

Citations - 53 (as of July 2017)

Methylprednisolone for acute spinal cord injury: an inappropriate standard of care.
Hurlbert RJ.
J Neurosurg. 2000 Jul;93(1 Suppl):1-7.

Rationale for inclusion: Results from the NASCIS II and III trials were reanalyzed without post-hoc comparisons and failed to show any benefit from the use of methylprednisolone and recovery from SCI.

Citations - 500 (as of July 2017)

Recent trends in mortality and causes of death among persons with spinal cord injury.
DeVivo MJ, Krause JS, Lammertse DP.
Arch Phys Med Rehabil. 1999 Nov;80(11):1411-9.

Rationale for inclusion: Mortality improved over a 25 year period from 1973 to 1998 in spinal cord injury care systems and Shriner's Hospitals.

Citations - 821 (as of July 2017)

Surgical management of spinal epidural hematoma: relationship between surgical timing and neurological outcome.
Lawton MT, Porter RW, Heiserman JE, Jacobowitz R, Sonntag VK, Dickman CA.
J Neurosurg. 1995 Jul;83(1):1-7.

Rationale for inclusion: Preoperative neurologic status correlated and time to surgical evacuation correlated with outcomes.

Citations - 572 (as of July 2017)

Methylprednisolone or naloxone treatment after acute spinal cord injury: 1-year follow-up data. Results of the second National Acute Spinal Cord Injury Study.
Bracken MB, Shepard MJ, Collins WF Jr, Holford TR, Baskin DS, Eisenberg HM, Flamm E, Leo-Summers L, Maroon JC, Marshall LF, et al.
J Neurosurg. 1992 Jan;76(1):23-31.

Rationale for inclusion: Results from the NASCIS II trial were preserved at 1 year followup.

CAVEAT: Later reanalyzed and failed to show improvement in primary outcome measures.

Citations - 769 (as of July 2017)

A randomized, controlled trial of methylprednisolone or naloxone in the treatment of acute spinal-cord injury. Results of the Second National Acute Spinal Cord Injury Study.
Bracken MB, Shepard MJ, Collins WF, Holford TR, Young W, Baskin DS, Eisenberg HM, Flamm E, Leo-Summers L, Maroon J, et al.
N Engl J Med. 1990 May 17;322(20):1405-11.

Rationale for inclusion: Patients treated with methylprednisolone within 8 hours of SCI had improved neurologic recovery at 6 months.

CAVEAT: Later reanalyzed and failed to show improvement in primary outcome measures.

Citations - 2720 (as of July 2017)

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