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Burn Scar Management

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Key Cell Functions are Modulated by Compression in an Animal Model of Hypertrophic Scar.
Alkhalil A, Carney BC, Travis TE, Muhie S, Miller SA, Ramella-Roman JC, Ghassemi P, Hammamieh R, Jett M, Moffatt LT, Shupp JW.
Wounds. 2018 Dec;30(12):353-362. Epub 2018 Sep 30.

Rationale for inclusion: Compression has been known to impact scar maturation in burn patients for decades. Understanding of the cellular mechanisms for this modulation has been lacking; this paper identifies broad transcriptome changes in scar after the application of measured compression.

CAVEAT: Animal work

Citations  - To review the number of citations for this landmark paper, visit Google Scholar.

Gabapentin for the treatment of itching produced by burns and wound healing in children: a pilot study.
Mendham JE.
Burns. 2004 Dec;30(8):851-3.

Rationale for inclusion: Literature describing use of gabapentin in the treatment of children with post-burn injury itch. 35 kids who were on other medications with persistent itch were treated with gabapentin and all had improvements in itching with the medication. 

CAVEAT: Single center, pediatric only, not randomized or otherwise controlled

Citations  - To review the number of citations for this landmark paper, visit Google Scholar.

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