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Burn Surgery

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Efficacy and safety of a fibrin sealant for adherence of autologous skin grafts to burn wounds: results of a phase 3 clinical study.
Foster K, Greenhalgh D, Gamelli RL, Mozingo D, Gibran N, Neumeister M, Abrams SZ, Hantak E, Grubbs L, Ploder B, Schofield N, Riina LH; FS 4IU VH S/D Clinical Study Group.
J Burn Care Res. 2008 Mar-Apr;29(2):293-303.

Rationale for inclusion: Phase 3, multicentered, prospective, randomized, evaluator-blinded, clinical study was to compare skin graft adherence utilizing ARTISS. Results demonstrated that fibrin glue was safe and effective for skin grafting with outcomes as good or better than staple fixation. 

Citations  - To review the number of citations for this landmark paper, visit Google Scholar.

Meta-analysis of early excision of burns.
Ong YS, Samuel M, Song C.
Burns. 2006 Mar;32(2):145-50. Epub

Rationale for inclusion: Meta-analysis of existing literature demonstrating early excision to be associated with decreased mortality and hospital length of stay.

CAVEAT: Meta-analysis

Citations  - To review the number of citations for this landmark paper, visit Google Scholar.

Excision and grafting of large burns: operation length not related to increased morbidity.
Foy HM, Pavlin ED, Heimbach DM.
J Trauma. 1986 Jan;26(1):51-3.

Rationale for inclusion: Retrospective single center study evaluating operative length as a risk factor for mortality. Long-operations, in this study, were those that lasted 180 min or more. The % excised was only slightly more in the long group, 14% compared to 11% but the authors found that operative length was not a risk factor for mortality in this cohort. 

CAVEAT: Single center, retrospective

Citations  - To review the number of citations for this landmark paper, visit Google Scholar.

Early surgical excision versus conventional therapy in patients with 20 to 40 percent burns. A comparative study.
Gray DT, Pine RW, Harnar TJ, Marvin JA, Engrav LH, Heimbach DM.
Am J Surg. 1982 Jul;144(1):76-80.

Rationale for inclusion: Retrospective, single center study comparing a historical cohort with a more recent cohort in which early excision was the standard approach. One of the first papers critically looking at, what was at the time, an emerging treatment paradigm. 

CAVEAT: Retrospective historical cohort study at a single center. Study from 1982, many improvements have been made in both burn care and critical care since that time.

Citations  - To review the number of citations for this landmark paper, visit Google Scholar.

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