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Inhalation Injury

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High-frequency percussive ventilation and low tidal volume ventilation in burns: a randomized controlled trial.
Chung KK, Wolf SE, Renz EM, Allan PF, Aden JK, Merrill GA, Shelhamer MC, King BT, White CE, Bell DG, Schwacha MG, Wanek SM, Wade CE, Holcomb JB, Blackbourne LH, Cancio LC.
Crit Care Med. 2010 Oct;38(10):1970-7.

Rationale for inclusion: Randomized controlled trial evaluating the use of ARDSNet recommendations to a patient population not included in the original LPS studies. Suggests that lung protective strategy in not a one-size-fits-all approach for the critically ill burn patient.

CAVEAT: Group has significant experience with HFOV, not used in a large number of other centers

Citations  - To review the number of citations for this landmark paper, visit Google Scholar.

Carboxyhemoglobin half-life in carbon monoxide-poisoned patients treated with 100% oxygen at atmospheric pressure.
Weaver LK, Howe S, Hopkins R, Chan KJ.
Chest. 2000 Mar;117(3):801-8.

Rationale for inclusion: Retrospective chart review evaluating the half-life of carbon monoxide in patients revealing that the half-life of carboxyhemoglobin was approximately 74 minutes on 100% O2. They demonstrate that half-life was influenced only by the patient's PaO2.

CAVEAT: Retrospective chart review

Citations  - To review the number of citations for this landmark paper, visit Google Scholar.

Effect of inhalation injury on fluid resuscitation requirements after thermal injury.
Navar PD, Saffle JR, Warden GD.
Am J Surg. 1985 Dec;150(6):716-20.

Rationale for inclusion: Study describing the increased fluid resuscitation needs in patients with inhalation injuries in the presence of severe thermal injury. 

CAVEAT: Single center, retrospective.

Citations  - To review the number of citations for this landmark paper, visit Google Scholar.

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