Prehospital and Resuscitation
- A comparison of high-dose and standard-dose epinephrine in children with cardiac arrest.
- Perondi MB1, Reis AG, Paiva EF, Nadkarni VM, Berg RA.
- N Engl J Med. 2004 Apr 22;350(17):1722-30.
Rationale for inclusion: This prospective, randomized, double-blind study of 68 children showed that patients in the high-dose group (0.1 mg/kg) had no difference in return of spontaneous circulation and worse 24-hour mortality and survival to discharge compared to standard dose (0.01 mg/kg) epinephrine.
Citations - 247 (as of July 2017)
- Predicting survival in pediatric trauma patients receiving cardiopulmonary resuscitation in the prehospital setting.
- Perron AD, Sing RF, Branas CC, Huynh T.
- Prehosp Emerg Care. 2001 Jan-Mar;5(1):6-9.
Rationale for inclusion: This study was a large, retrospective registry review of 729 pediatric trauma patients receiving CPR in the field from 1998-2005. The authors found that prehospital intubation, penetrating mechanism, and receiving additional CPR at the trauma center were predictors of mortality. Overall mortality was 29%.
CAVEAT: Retrospective, trauma registry
Citations - 47 (as of July 2017)
- Early fluid resuscitation improves outcomes in severely burned children.
- Barrow RE, Jeschke MG, Herndon DN.
- Resuscitation. 2000 Jul;45(2):91-6.
Rationale for inclusion: This single institution, retrospective review of 133 children with greater than 50% TBSA burns showed that sepsis, acute kidney injury, and overall mortality was significantly increased when initiation of fluid resuscitation was delayed by two hours or more.
CAVEAT: Single institution, retrospective
Citations - 133 (as of July 2017)
- Effect of out-of-hospital pediatric endotracheal intubation on survival and neurological outcome: a controlled clinical trial.
- Gausche M, Lewis RJ, Stratton SJ, Haynes BE, Gunter CS, Goodrich SM, Poore PD, McCollough MD, Henderson DP, Pratt FD, Seidel JS.
- JAMA. 2000 Feb 9;283(6):783-90.
Rationale for inclusion: This prospective, randomized (by odd/even date of arrest), observational, multi-center evaluation of 830 pediatric patients requiring advanced airway management from 1994-1997 compared prehospital endotracheal intubation (N=420) to bag mask ventilation (BVM) (N=410) and found no difference in survival or neurologic outcome. This suggests that BVM is sufficient for prehospital management of the pediatric airway.
Citations - 762 (as of July 2017)