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Endocrine - Gylcemic Control

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Hypoglycemia and risk of death in critically ill patients.
NICE-SUGAR Study Investigators, Finfer S, Liu B, Chittock DR, Norton R, Myburgh JA, McArthur C, Mitchell I, Foster D, Dhingra V, Henderson WR, Ronco JJ, Bellomo R, Cook D, McDonald E, Dodek P, Hébert PC, Heyland DK, Robinson BG.
N Engl J Med. 2012 Sep 20;367(12):1108-18.

Rationale for inclusion: Association between hypoglycemia seen in intensive glycemic control and mortality.

Citations  - To review the number of citations for this landmark paper, visit Google Scholar.

Glucose variability is associated with intensive care unit mortality.
Hermanides J, Vriesendorp TM, Bosman RJ, Zandstra DF, Hoekstra JB, Devries JH.
Crit Care Med. 2010 Mar;38(3):838-42.

Rationale for inclusion: Strong association of glucose variability and mortality.

Citations  - To review the number of citations for this landmark paper, visit Google Scholar.

Intensive versus conventional glucose control in critically ill patients.
NICE-SUGAR Study Investigators, Finfer S, Chittock DR, Su SY, Blair D, Foster D, Dhingra V, Bellomo R, Cook D, Dodek P, Henderson WR, Hébert PC, Heritier S, Heyland DK, McArthur C, McDonald E, Mitchell I, Myburgh JA, Norton R, Potter J, Robinson BG, Ronco JJ.
N Engl J Med. 2009 Mar 26;360(13):1283-97.

Rationale for inclusion: NICE-SUGAR study: increased mortality in intensive glucose control.

Citations  - To review the number of citations for this landmark paper, visit Google Scholar.

Glycemic variability: a strong independent predictor of mortality in critically ill patients.
Krinsley JS.
Crit Care Med. 2008 Nov;36(11):3008-13.

Rationale for inclusion: Variation in glucose levels is independent factor of mortality in ICU  

Citations  - To review the number of citations for this landmark paper, visit Google Scholar.

Benefits and risks of tight glucose control in critically ill adults: a meta-analysis.
Wiener RS, Wiener DC, Larson RJ.
JAMA. 2008 Aug 27;300(8):933-44.

Rationale for inclusion: Meta analysis showing effect of tight glycemic control on episodes of hypoglycemia and no decreased mortality.

Citations  - To review the number of citations for this landmark paper, visit Google Scholar.

Reliability of point-of-care testing for glucose measurement in critically ill adults.
Kanji S, Buffie J, Hutton B, Bunting PS, Singh A, McDonald K, Fergusson D, McIntyre LA, Hebert PC.
Crit Care Med. 2005 Dec;33(12):2778-85.

Rationale for inclusion: Variability of glucose measurement methods

Citations  - To review the number of citations for this landmark paper, visit Google Scholar.

Crit Care Med. 2003 Feb;31(2):359-66.
Van den Berghe G, Wouters PJ, Bouillon R, Weekers F, Verwaest C, Schetz M, Vlasselaers D, Ferdinande P, Lauwers P.
Crit Care Med. 2003 Feb;31(2):359-66.

Rationale for inclusion: Classic: Intensive glucose control is beneficial (later proven wrong).

Citations  - To review the number of citations for this landmark paper, visit Google Scholar.

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