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HEME - Acute Anemia

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Age of Red Cells for Transfusion and Outcomes in Critically Ill Adults.
Cooper DJ, McQuilten ZK, Nichol A, Ady B, Aubron C, Bailey M, Bellomo R, Gantner D, Irving DO, Kaukonen KM, McArthur C, Murray L, Pettilä V, French C; TRANSFUSE Investigators and the Australian and New Zealand Intensive Care Society Clinical Trials Group.
N Engl J Med. 2017 Nov 9;377(19):1858-1867.

Rationale for inclusion: TRANSFUSE (Standard Issue Transfusion versus Fresher Red-Cell Use in Intensive Care) study assigned critically ill adults to either receive the oldest or freshest red cells available. This study found no difference in mortality between patients transfused fresh (mean 11.8 days of storage) vs. old (mean 22.4 days of storage) pRBCs. 

Citations  - To review the number of citations for this landmark paper, visit Google Scholar.

Transfusion requirements after cardiac surgery: the TRACS randomized controlled trial.
Hajjar LA, Vincent JL, Galas FR, Nakamura RE, Silva CM, Santos MH, Fukushima J, Kalil Filho R, Sierra DB, Lopes NH, Mauad T, Roquim AC, Sundin MR, Leão WC, Almeida JP, Pomerantzeff PM, Dallan LO, Jatene FB, Stolf NA, Auler JO Jr.
JAMA. 2010 Oct 13;304(14):1559-67.

Rationale for inclusion: The TRACS trial, the cardiac surgery version of the TRICC trial

Citations  - To review the number of citations for this landmark paper, visit Google Scholar.

Does the storage time of transfused red blood cells influence regional or global indexes of tissue oxygenation in anemic critically ill patients?
Walsh TS, McArdle F, McLellan SA, Maciver C, Maginnis M, Prescott RJ, McClelland DB.
Crit Care Med. 2004 Feb;32(2):364-71.

Rationale for inclusion: This study addresses part of the controversy of efficacy of stored blood products and oxygen delivery.

Citations  - To review the number of citations for this landmark paper, visit Google Scholar.

A multicenter, randomized, controlled clinical trial of transfusion requirements in critical care. Transfusion Requirements in Critical Care Investigators, Canadian Critical Care Trials Group.
Hébert PC, Wells G, Blajchman MA, Marshall J, Martin C, Pagliarello G, Tweeddale M, Schweitzer I, Yetisir E.
N Engl J Med. 1999 Feb 11;340(6):409-17.

Rationale for inclusion: The original TRICC trial that set the standard of Hb goal of 7.0.

Citations  - To review the number of citations for this landmark paper, visit Google Scholar.

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