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HEME - Coagulopathies

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Guideline for Reversal of Antithrombotics in Intracranial Hemorrhage: A Statement for Healthcare Professionals from the Neurocritical Care Society and Society of Critical Care Medicine.
Frontera JA, Lewin JJ 3rd, Rabinstein AA, Aisiku IP, Alexandrov AW, Cook AM, del Zoppo GJ, Kumar MA, Peerschke El, Stiefel MF, Teitelbaum JS, Wartenberg KE, Zerfoss CL.
Neurocrit Care. 2016 Feb;24(1):6-46.

Rationale for inclusion: This comprehensive guideline provides evidence-based reversal strategies for the reversal of vitamin K antagonists, direct Xa antagonists, direct thrombin inhibitors, heparins, and antiplatelet agents in the setting of intracranial hemorrhage. It was printed in both Critical Care Medicine and Neurocritical Care. 

Citations  - To review the number of citations for this landmark paper, visit Google Scholar.

Thromboelastography (TEG) and rotational thromboelastometry (ROTEM) for trauma induced coagulopathy in adult trauma patients with bleeding.
Hunt H, Stanworth S, Curry N, Woolley T, Cooper C, Ukoumunne O, Zhelev Z, Hyde C.
Cochrane Database Syst Rev. 2015 Feb 16;(2):CD010438.

Rationale for inclusion: Excellent review on the use of TEG / ROTEM in defining traumatic coagulopathy.

Citations  - To review the number of citations for this landmark paper, visit Google Scholar.

Transfusion of plasma, platelets, and red blood cells in a 1:1:1 vs a 1:1:2 ratio and mortality in patients with severe trauma: the PROPPR randomized clinical trial.
Holcomb JB, Tilley BC, Baraniuk S, Fox EE, Wade CE, Podbielski JM, del Junco DJ, Brasel KJ, Bulger EM, Callcut RA, Cohen MJ, Cotton BA, Fabian TC, Inaba K, Kerby JD, Muskat P, O'Keeffe T, Rizoli S, Robinson BR, Scalea TM, Schreiber MA, Stein DM, Weinberg JA, Callum JL, Hess JR, Matijevic N, Miller CN, Pittet JF, Hoyt DB, Pearson GD, Leroux B, van Belle G; PROPPR Study Group.
JAMA. 2015 Feb 3;313(5):471-82.

Rationale for inclusion: PROPPR trial that included patelet ratios in massive transfusion protocols

Citations  - To review the number of citations for this landmark paper, visit Google Scholar.

Evaluation and management of geriatric trauma: an Eastern Association for the Surgery of Trauma practice management guideline.
Calland JF, Ingraham AM, Martin N, Marshall GT, Schulman CI, Stapleton T, Barraco RD; Eastern Association for the Surgery of Trauma.
J Trauma Acute Care Surg. 2012 Nov;73(5 Suppl 4):S345-50.

Rationale for inclusion: EAST guideline on geriatric trauma which discusses the induced coagulopathies of pharmacy.

Citations  - To review the number of citations for this landmark paper, visit Google Scholar.

Results of the CONTROL trial: efficacy and safety of recombinant activated Factor VII in the management of refractory traumatic hemorrhage.
Hauser CJ, Boffard K, Dutton R, Bernard GR, Croce MA, Holcomb JB, Leppaniemi A, Parr M, Vincent JL, Tortella BJ, Dimsits J, Bouillon B; CONTROL Study Group.
J Trauma. 2010 Sep;69(3):489-500.

Rationale for inclusion: Highly referenced article on the use of Factor VII in traumatic hemmorrhage

Citations  - To review the number of citations for this landmark paper, visit Google Scholar.

Standard prophylactic enoxaparin dosing leads to inadequate anti-Xa levels and increased deep venous thrombosis rates in critically ill trauma and surgical patients.
Malinoski D, Jafari F, Ewing T, Ardary C, Conniff H, Baje M, Kong A, Lekawa ME, Dolich MO, Cinat ME, Barrios C, Hoyt DB.
J Trauma. 2010 Apr;68(4):874-80.

Rationale for inclusion: Highly referenced article on the use of Factor VII in traumatic hemmorrhage

Citations  - To review the number of citations for this landmark paper, visit Google Scholar.

Thrombocytopenia in the intensive care unit patient.
Greinacher A, Selleng K.
Hematology Am Soc Hematol Educ Program. 2010;2010:135-43.

Rationale for inclusion: Well-referenced paper on thrombocytopenia and the management thereof

Citations  - To review the number of citations for this landmark paper, visit Google Scholar.

Fresh whole blood transfusions in coalition military, foreign national, and enemy combatant patients during Operation Iraqi Freedom at a U.S. combat support hospital.
Spinella PC, Perkins JG, Grathwohl KW, Repine T, Beekley AC, Sebesta J, Jenkins D, Azarow K, Holcomb JB; 31st CSH Research Working Group.
World J Surg. 2008 Jan;32(1):2-6. Epub 2007 Nov 9.

Rationale for inclusion: Excellent results of fresh whole blood for hemmorrhage resuscitation in the military

Citations  - To review the number of citations for this landmark paper, visit Google Scholar.

Fresh frozen plasma should be given earlier to patients requiring massive transfusion.
Gonzalez EA, Moore FA, Holcomb JB, Miller CC, Kozar RA, Todd SR, Cocanour CS, Balldin BC, McKinley BA.
J Trauma. 2007 Jan;62(1):112-9.

Rationale for inclusion: Pinnicle article on civilian ratios of red cells to FFP; calling for 1:1 resuscitations

Citations  - To review the number of citations for this landmark paper, visit Google Scholar.

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