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Neuro - Agitation

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Dexmedetomidine reduces the risk of delirium, agitation and confusion in critically Ill patients: a meta-analysis of randomized controlled trials.
Pasin L, Landoni G, Nardelli P, Belletti A, Di Prima AL, Taddeo D, Isella F, Zangrillo A.
J Cardiothorac Vasc Anesth. 2014 Dec;28(6):1459-66.

Rationale for inclusion: This is one of many (but a more definitive) articles on value of dexmedetomidine use in the severely aggitated.

Citations  - To review the number of citations for this landmark paper, visit Google Scholar.

Implementing the awakening and breathing coordination, delirium monitoring/management, and early exercise/mobility bundle into everyday care: opportunities, challenges, and lessons learned for implementing the ICU Pain, Agitation, and Delirium Guidelines.
Balas MC, Burke WJ, Gannon D, Cohen MZ, Colburn L, Bevil C, Franz D, Olsen KM, Ely EW, Vasilevskis EE.
Crit Care Med. 2013 Sep;41(9 Suppl 1):S116-27.

Rationale for inclusion: Important follow up study of the "wake up and breath" campaign to show efficacy.

Citations  - To review the number of citations for this landmark paper, visit Google Scholar.

Clinical practice guidelines for the management of pain, agitation, and delirium in adult patients in the intensive care unit.
Barr J, Fraser GL, Puntillo K, Ely EW, GĂ©linas C, Dasta JF, Davidson JE, Devlin JW, Kress JP, Joffe AM, Coursin DB, Herr DL, Tung A, Robinson BR, Fontaine DK, Ramsay MA, Riker RR, Sessler CN, Pun B, Skrobik Y, Jaeschke R; American College of Critical Care Medicine.
Crit Care Med. 2013 Jan;41(1):263-306.

Rationale for inclusion: Clinical practice guidelines for pain, agitation and delirium in the ICU.

Citations  - To review the number of citations for this landmark paper, visit Google Scholar.

The Richmond Agitation-Sedation Scale: validity and reliability in adult intensive care unit patients.
Sessler CN, Gosnell MS, Grap MJ, Brophy GM, O'Neal PV, Keane KA, Tesoro EP, Elswick RK.
Am J Respir Crit Care Med. 2002 Nov 15;166(10):1338-44.

Rationale for inclusion: This is the original paper describing the validity of RASS which is still the most used method of sedation/agitation scoring.

Citations  - To review the number of citations for this landmark paper, visit Google Scholar.

Prolongation of the corrected QT and torsades de pointes cardiac arrhythmia associated with intravenous haloperidol in the medically ill.
Metzger E, Friedman R.
J Clin Psychopharmacol. 1993 Apr;13(2):128-32.

Rationale for inclusion: This article is responsible for the current practice of QT tracking with the use of Haldol and other neuroleptics such as Seroquel.

Citations  - To review the number of citations for this landmark paper, visit Google Scholar.

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