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Neuro - Delirium

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Effect of Haloperidol on Survival Among Critically Ill Adults With a High Risk of Delirium
Mark van den Boogaard, PhD,corresponding author1 Arjen J. C. Slooter, MD, PhD, Roger J. M. Brüggemann, PharmD, PhD, Lisette Schoonhoven, PhD, Albertus Beishuizen, MD, PhD, J. Wytze Vermeijden, MD, PhD, Danie Pretorius, MD, Jan de Koning, MD, Koen S. Simons, MD, Paul J. W. Dennesen, MD, PhD, Peter H. J. Van der Voort, MD, PhD, Saskia Houterman, PhD, J. G. van der Hoeven, MD, PhD, and Peter Pickkers, MD, PhD
JAMA. 2018 Feb 20; 319(7): 680–690. Published online 2018 Feb 20.

Rationale for inclusion: REDUCE RCT evaluating use of haloperidol v placebo in critically ill patients at high risk of delirium

Citations  - To review the number of citations for this landmark paper, visit Google Scholar.

Statin and Its Association With Delirium in the Medical ICU.
Mather JF, Corradi JP, Waszynski C, Noyes A, Duan Y, Grady J, Dicks R.
Crit Care Med. 2017 Sep;45(9):1515-1522.

Rationale for inclusion: Retrospective cohort analysis examining association between statin use and risk of delirium.

Citations  - To review the number of citations for this landmark paper, visit Google Scholar.

Statins and delirium during critical illness: a multicenter, prospective cohort study.
Morandi A, Hughes CG, Thompson JL, Pandharipande PP, Shintani AK, Vasilevskis EE, Han JH, Jackson JC, Laskowitz DT, Bernard GR, Ely EW, Girard TD.
Crit Care Med. 2014 Aug;42(8):1899-909.

Rationale for inclusion: Multicenter prospective cohort study evaluating effective of statin exposure on delirium in the ICU.

Citations  - To review the number of citations for this landmark paper, visit Google Scholar.

Clinical practice guidelines for the management of pain, agitation, and delirium in adult patients in the intensive care unit.
Barr J, Fraser GL, Puntillo K, Ely EW, Gélinas C, Dasta JF, Davidson JE, Devlin JW, Kress JP, Joffe AM, Coursin DB, Herr DL, Tung A, Robinson BR, Fontaine DK, Ramsay MA, Riker RR, Sessler CN, Pun B, Skrobik Y, Jaeschke R; American College of Critical Care Medicine.
Crit Care Med. 2013 Jan;41(1):263-306.

Rationale for inclusion: Clinical practice guidelines for pain, agitation and delirium in the ICU.

Citations  - To review the number of citations for this landmark paper, visit Google Scholar.

Delirium in mechanically ventilated patients: validity and reliability of the confusion assessment method for the intensive care unit (CAM-ICU).
Ely EW, Inouye SK, Bernard GR, Gordon S, Francis J, May L, Truman B, Speroff T, Gautam S, Margolin R, Hart RP, Dittus R.
JAMA. 2001 Dec 5;286(21):2703-10.

Rationale for inclusion: Original description of CAM-ICU and its validation.

Citations  - To review the number of citations for this landmark paper, visit Google Scholar.

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