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Neuro - Sedation

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Daily sedation interruption in mechanically ventilated critically ill patients cared for with a sedation protocol: a randomized controlled trial.
Mehta S, Burry L, Cook D, Fergusson D, Steinberg M, Granton J, Herridge M, Ferguson N, Devlin J, Tanios M, Dodek P, Fowler R, Burns K, Jacka M, Olafson K, Skrobik Y, Hébert P, Sabri E, Meade M; SLEAP Investigators; Canadian Critical Care Trials Group.
JAMA. 2012 Nov 21;308(19):1985-92.

Rationale for inclusion: randomized multicentered trial evaluating the effectiveness of protocolized sedation with daily sedation interruption in the ICU.

Citations  - To review the number of citations for this landmark paper, visit Google Scholar.

Dexmedetomidine vs midazolam or propofol for sedation during prolonged mechanical ventilation: two randomized controlled trials.
Jakob SM, Ruokonen E, Grounds RM, Sarapohja T, Garratt C, Pocock SJ, Bratty JR, Takala J; Dexmedetomidine for Long-Term Sedation Investigators.
JAMA. 2012 Mar 21;307(11):1151-60.

Rationale for inclusion: Multicentered, randomized double blind trials (MIDEX and PRODEX trial) comparing the effectiveness of popular sedation medications in maintaining sedation.

Citations  - To review the number of citations for this landmark paper, visit Google Scholar.

A protocol of no sedation for critically ill patients receiving mechanical ventilation: a randomised trial.
Strøm T, Martinussen T, Toft P.
Lancet. 2010 Feb 6;375(9713):475-80.

Rationale for inclusion: Randomized trial evaluating whether no sedation v daily sedation interruptions had an effect on mechanical ventialtion duration.

Citations  - To review the number of citations for this landmark paper, visit Google Scholar.

Dexmedetomidine vs midazolam for sedation of critically ill patients: a randomized trial.
Riker RR, Shehabi Y, Bokesch PM, Ceraso D, Wisemandle W, Koura F, Whitten P, Margolis BD, Byrne DW, Ely EW, Rocha MG; SEDCOM (Safety and Efficacy of Dexmedetomidine Compared With Midazolam) Study Group.
JAMA. 2009 Feb 4;301(5):489-99.

Rationale for inclusion: One of the better head-to-head trials of dexmedetomidine vs versed in a RCT.

Citations  - To review the number of citations for this landmark paper, visit Google Scholar.

Efficacy and safety of a paired sedation and ventilator weaning protocol for mechanically ventilated patients in intensive care (Awakening and Breathing Controlled trial): a randomised controlled trial.
Girard TD, Kress JP, Fuchs BD, Thomason JW, Schweickert WD, Pun BT, Taichman DB, Dunn JG, Pohlman AS, Kinniry PA, Jackson JC, Canonico AE, Light RW, Shintani AK, Thompson JL, Gordon SM, Hall JB, Dittus RS, Bernard GR, Ely EW.
Lancet. 2008 Jan 12;371(9607):126-34.

Rationale for inclusion: Original "Wake up and Breath" trial.

Citations  - To review the number of citations for this landmark paper, visit Google Scholar.

Daily interruption of sedative infusions in critically ill patients undergoing mechanical ventilation.
Kress JP, Pohlman AS, O'Connor MF, Hall JB.
N Engl J Med. 2000 May 18;342(20):1471-7.

Rationale for inclusion: This paper describes the original "daily sedation holidays" which were popular and should be known for historic purposes.  Today, light sedation at all times is the goal, as per "the wake up and breath" campaign.

Citations  - To review the number of citations for this landmark paper, visit Google Scholar.

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