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Neuro - Sleep

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Effect of Administration of Ramelteon, a Melatonin Receptor Agonist, on the Duration of Stay in the ICU: A Single-Center Randomized Placebo-Controlled Trial.
Nishikimi M, Numaguchi A, Takahashi K, Miyagawa Y, Matsui K, Higashi M, Makishi G, Matsui S, Matsuda N.
Crit Care Med. 2018 Jul;46(7):1099-1105.

Rationale for inclusion: Single center triple blinded RCT comparing effects of ramelteon v placebo on delirium and ICU stay of critically ill patients.

Citations  - To review the number of citations for this landmark paper, visit Google Scholar.

Melatonin for the promotion of sleep in adults in the intensive care unit.
Lewis SR, Pritchard MW, Schofield-Robinson OJ, Alderson P, Smith AF.
Cochrane Database Syst Rev. 2018 May 10;5:CD012455.

Rationale for inclusion: Cochrane review evaluating the effectiveness of melatonin on quantity and quality of sleep in the ICU.

Citations  - To review the number of citations for this landmark paper, visit Google Scholar.

Postoperative complications in obstructive sleep apnea.
Mador MJ, Goplani S, Gottumukkala VA, El-Solh AA, Akashdeep K, Khadka G, Abo-Khamis M.
Sleep Breath. 2013 May;17(2):727-34.

Rationale for inclusion: This study describes the importance of OSA and its ill-toward effects on ICU outcome.

Citations  - To review the number of citations for this landmark paper, visit Google Scholar.

Abnormal sleep/wake cycles and the effect of environmental noise on sleep disruption in the intensive care unit.
Freedman NS, Gazendam J, Levan L, Pack AI, Schwab RJ.
Am J Respir Crit Care Med. 2001 Feb;163(2):451-7.

Rationale for inclusion: Pinnacle study on the importance of sleep hygiene in the ICU setting and the prevention of delirium.

Citations  - To review the number of citations for this landmark paper, visit Google Scholar.

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