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Neuro - Thermoregulation

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Revisited: A Systematic Review of Therapeutic Hypothermia for Adult Patients Following Traumatic Brain Injury.
Watson HI, Shepherd AA, Rhodes JKJ, Andrews PJD.
Send to Crit Care Med. 2018 Jun;46(6):972-979.

Rationale for inclusion: Cochrane study evaluating all RCT studies between 2011 and 2018 re therapeutic hypothermia

Citations  - To review the number of citations for this landmark paper, visit Google Scholar.

Hypothermia for Intracranial Hypertension after Traumatic Brain Injury.
Andrews PJ, Sinclair HL, Rodriguez A, Harris BA, Battison CG, Rhodes JK, Murray GD; Eurotherm Trial Collaborators.
N Engl J Med. 2015 Dec 17;373(25):2403-12.

Rationale for inclusion: International multicentered study comparing standard care to hypothermia (32-35C) plus standard care in TBI.

Citations  - To review the number of citations for this landmark paper, visit Google Scholar.

Targeted temperature management at 33°C versus 36°C after cardiac arrest.
Nielsen N, Wetterslev J, Cronberg T, Erlinge D, Gasche Y, Hassager C, Horn J, Hovdenes J, Kjaergaard J, Kuiper M, Pellis T, Stammet P, Wanscher M, Wise MP, Åneman A, Al-Subaie N, Boesgaard S, Bro-Jeppesen J, Brunetti I, Bugge JF, Hingston CD, Juffermans NP, Koopmans M, Køber L, Langørgen J, Lilja G, Møller JE, Rundgren M, Rylander C, Smid O, Werer C, Winkel P, Friberg H; TTM Trial Investigators.
N Engl J Med. 2013 Dec 5;369(23):2197-206.

Rationale for inclusion: A well referenced paper helping to dial in the perfect temperature goal.  Its findings suggested perhaps the real goals of targeted temperature management are to simply prevent hyperthermia.

Citations  - To review the number of citations for this landmark paper, visit Google Scholar.

Fever control using external cooling in septic shock: a randomized controlled trial.
Schortgen F, Clabault K, Katsahian S, Devaquet J, Mercat A, Deye N, Dellamonica J, Bouadma L, Cook F, Beji O, Brun-Buisson C, Lemaire F, Brochard L.
Am J Respir Crit Care Med. 2012 May 15;185(10):1088-95.

Rationale for inclusion: Multicenter RCT comparing febrile septic shock patients to external cooling v no cooling, evaluating vasopressor requirements.

Citations  - To review the number of citations for this landmark paper, visit Google Scholar.

Treatment of comatose survivors of out-of-hospital cardiac arrest with induced hypothermia.
Bernard SA, Gray TW, Buist MD, Jones BM, Silvester W, Gutteridge G, Smith K.
N Engl J Med. 2002 Feb 21;346(8):557-63.

Rationale for inclusion: This paper is the basis for therapeutic hypothermia that has been extrapolated into in-hospital and traumatic arrests as well.

Citations  - To review the number of citations for this landmark paper, visit Google Scholar.

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