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Neuro - Thermoregulation

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Targeted temperature management at 33°C versus 36°C after cardiac arrest.
Nielsen N, Wetterslev J, Cronberg T, Erlinge D, Gasche Y, Hassager C, Horn J, Hovdenes J, Kjaergaard J, Kuiper M, Pellis T, Stammet P, Wanscher M, Wise MP, Åneman A, Al-Subaie N, Boesgaard S, Bro-Jeppesen J, Brunetti I, Bugge JF, Hingston CD, Juffermans NP, Koopmans M, Køber L, Langørgen J, Lilja G, Møller JE, Rundgren M, Rylander C, Smid O, Werer C, Winkel P, Friberg H; TTM Trial Investigators.
N Engl J Med. 2013 Dec 5;369(23):2197-206.

Rationale for inclusion: A well referenced paper helping to dial in the perfect temperature goal.  Its findings suggested perhaps the real goals of targeted temperature management are to simply prevent hyperthermia.

Citations - 1275 (as of July 2017)

Treatment of comatose survivors of out-of-hospital cardiac arrest with induced hypothermia.
Bernard SA, Gray TW, Buist MD, Jones BM, Silvester W, Gutteridge G, Smith K.
N Engl J Med. 2002 Feb 21;346(8):557-63.

Rationale for inclusion: This paper is the basis for therapeutic hypothermia that has been extrapolated into in-hospital and traumatic arrests as well.

Citations - 4784 (as of July 2017)

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