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Renal - Acute Kidney Injury

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Effect of a Buffered Crystalloid Solution vs Saline on Acute Kidney Injury Among Patients in the Intensive Care Unit: The SPLIT Randomized Clinical Trial.
Young P, Bailey M, Beasley R, Henderson S, Mackle D, McArthur C, McGuinness S, Mehrtens J, Myburgh J, Psirides A, Reddy S, Bellomo R; SPLIT Investigators; ANZICS CTG.
JAMA. 2015 Oct 27;314(16):1701-10.

Rationale for inclusion: Prospective trial: Buffered crystalloids did not reduce risk of AKI compared to NS.

Citations - 177 (as of July 2017)

Association between the choice of IV crystalloid and in-hospital mortality among critically ill adults with sepsis*.
Raghunathan K, Shaw A, Nathanson B, Stürmer T, Brookhart A, Stefan MS, Setoguchi S, Beadles C, Lindenauer PK.
Crit Care Med. 2014 Jul;42(7):1585-91.

Rationale for inclusion: Balanced fluids (e.g. LR) was associated with improved mortlity compared to normal saline - retrospective, propensity-matched.

Citations - 159 (as of July 2017)

Effects of fluid resuscitation with colloids vs crystalloids on mortality in critically ill patients presenting with hypovolemic shock: the CRISTAL randomized trial.
Annane D, Siami S, Jaber S, Martin C, Elatrous S, Declère AD, Preiser JC, Outin H, Troché G, Charpentier C, Trouillet JL, Kimmoun A, Forceville X, Darmon M, Lesur O, Reignier J, Abroug F, Berger P, Clec'h C, Cousson J, Thibault L, Chevret S; CRISTAL Investigators.
JAMA. 2013 Nov 6;310(17):1809-17.

Rationale for inclusion: CRISTAL trial: No difference in mortality between colloids and crystalloids.

Citations - 367 (as of July 2017)

Hydroxyethyl starch or saline for fluid resuscitation in intensive care.
Myburgh JA, Finfer S, Bellomo R, Billot L, Cass A, Gattas D, Glass P, Lipman J, Liu B, McArthur C, McGuinness S, Rajbhandari D, Taylor CB, Webb SA; CHEST Investigators; Australian and New Zealand Intensive Care Society Clinical Trials Group.
N Engl J Med. 2012 Nov 15;367(20):1901-11.

Rationale for inclusion: HES associated with increased need for CRRT but not mortality.

Citations - 1057 (as of July 2017)

Fluid overload is associated with an increased risk for 90-day mortality in critically ill patients with renal replacement therapy: data from the prospective FINNAKI study.
Vaara ST, Korhonen AM, Kaukonen KM, Nisula S, Inkinen O, Hoppu S, Laurila JJ, Mildh L, Reinikainen M, Lund V, Parviainen I, Pettilä V; FINNAKI Study Group.
Crit Care. 2012 Oct 17;16(5):R197.

Rationale for inclusion: Significant increase in mortality in ICU patients with volume overload at initiation of CRRT.

Citations - 148 (as of July 2017)

Hydroxyethyl starch 130/0.42 versus Ringer's acetate in severe sepsis.
Perner A, Haase N, Guttormsen AB, Tenhunen J, Klemenzson G, Åneman A, Madsen KR, Møller MH, Elkjær JM, Poulsen LM, Bendtsen A, Winding R, Steensen M, Berezowicz P, Søe-Jensen P, Bestle M, Strand K, Wiis J, White JO, Thornberg KJ, Quist L, Nielsen J, Andersen LH, Holst LB, Thormar K, Kjældgaard AL, Fabritius ML, Mondrup F, Pott FC, Møller TP, Winkel P, Wetterslev J; 6S Trial Group; Scandinavian Critical Care Trials Group.
N Engl J Med. 2012 Jul 12;367(2):124-34.

Rationale for inclusion: HES associated with increased mortality and renal failure.

Citations - 1224 (as of July 2017)

Fluid resuscitation in septic shock: a positive fluid balance and elevated central venous pressure are associated with increased mortality.
Boyd JH, Forbes J, Nakada TA, Walley KR, Russell JA.
Crit Care Med. 2011 Feb;39(2):259-65.

Rationale for inclusion: Positive fluid balance associated with increased mortality.

Citations - 818 (as of July 2017)

Comparison of two fluid-management strategies in acute lung injury.
National Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome (ARDS) Clinical Trials Network, Wiedemann HP, Wheeler AP, Bernard GR, Thompson BT, Hayden D, deBoisblanc B, Connors AF Jr, Hite RD, Harabin AL.
N Engl J Med. 2006 Jun 15;354(24):2564-75.

Rationale for inclusion: Conservative fluid management decreased duration of mechanical ventilation in acute lung injury without increase in other organs' dysfunction- though no difference in mortality at 60 days.

Citations - 1 (as of July 2017)

A randomized, controlled trial of furosemide with or without albumin in hypoproteinemic patients with acute lung injury.
Martin GS, Moss M, Wheeler AP, Mealer M, Morris JA, Bernard GR.
Crit Care Med. 2005 Aug;33(8):1681-7.

Rationale for inclusion: Randomized double blinded trial - addition of Albumin facilitates achieving negative balance without compromising hemodynamics or oxygenation in hypoalbuminic patients.

Citations - 315 (as of July 2017)

A comparison of albumin and saline for fluid resuscitation in the intensive care unit.
Finfer S, Bellomo R, Boyce N, French J, Myburgh J, Norton R; SAFE Study Investigators.
N Engl J Med. 2004 May 27;350(22):2247-56.

Rationale for inclusion: SAFE Trial: Similar outcome between albumin and saline in ICU.

Citations - 2338 (as of July 2017)

Supranormal trauma resuscitation causes more cases of abdominal compartment syndrome.
Balogh Z, McKinley BA, Cocanour CS, Kozar RA, Valdivia A, Sailors RM, Moore FA.
Arch Surg. 2003 Jun;138(6):637-42; discussion 642-3.

Rationale for inclusion: Unfavorable outcomes associated with supranormal resuscitation (defined by oxygen delivery index goals).

Citations - 487 (as of July 2017)

Crystalloids vs. colloids in fluid resuscitation: a systematic review.
Choi PT, Yip G, Quinonez LG, Cook DJ.
Crit Care Med. 1999 Jan;27(1):200-10.

Rationale for inclusion: Systemic review: no difference between crystalloids or colloids, except in trauma (favoring crystalloids).

Citations - 778 (as of July 2017)

Fluid balance during pulmonary edema. Is fluid gain a marker or a cause of poor outcome?
Schuller D, Mitchell JP, Calandrino FS, Schuster DP.
Chest. 1991 Oct;100(4):1068-75.

Rationale for inclusion: Importance of avoiding significant gains in fluid balances.

Citations - 262 (as of July 2017)

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