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Respiratory - Acute Lung Injury / ARDS

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Prone positioning in severe acute respiratory distress syndrome.
Guérin C, Reignier J, Richard JC, Beuret P, Gacouin A, Boulain T, Mercier E, Badet M, Mercat A, Baudin O, Clavel M, Chatellier D, Jaber S, Rosselli S, Mancebo J, Sirodot M, Hilbert G, Bengler C, Richecoeur J, Gainnier M, Bayle F, Bourdin G, Leray V, Girard R, Baboi L, Ayzac L; PROSEVA Study Group.
N Engl J Med. 2013 Jun 6;368(23):2159-68.

Rationale for inclusion: The last word on prone positioning - in favor of early prone positioning for ARDS.

Citations - 975 (as of July 2017)

High-frequency oscillation in early acute respiratory distress syndrome.
Ferguson ND, Cook DJ, Guyatt GH, Mehta S, Hand L, Austin P, Zhou Q, Matte A, Walter SD, Lamontagne F, Granton JT, Arabi YM, Arroliga AC, Stewart TE, Slutsky AS, Meade MO; OSCILLATE Trial Investigators; Canadian Critical Care Trials Group.
N Engl J Med. 2013 Feb 28;368(9):795-805.

Rationale for inclusion: With the Young study, one of the articles that ended trials on HFOV.

Citations - 471 (as of July 2017)

The Berlin definition of ARDS: an expanded rationale, justification, and supplementary material.
Ferguson ND, Fan E, Camporota L, Antonelli M, Anzueto A, Beale R, Brochard L, Brower R, Esteban A, Gattinoni L, Rhodes A, Slutsky AS, Vincent JL, Rubenfeld GD, Thompson BT, Ranieri VM.
Intensive Care Med. 2012 Oct;38(10):1573-82.

Rationale for inclusion: The Berlin criteria for ALI and ARDS.

Citations - 535 (as of July 2017)

Neuromuscular blockers in early acute respiratory distress syndrome.
Papazian L, Forel JM, Gacouin A, Penot-Ragon C, Perrin G, Loundou A, Jaber S, Arnal JM, Perez D, Seghboyan JM, Constantin JM, Courant P, Lefrant JY, Guérin C, Prat G, Morange S, Roch A; ACURASYS Study Investigators.
N Engl J Med. 2010 Sep 16;363(12):1107-16.

Rationale for inclusion: Early use of NMBA decreases vent days, mortality and has no effect on ICU acquired weakness.

Citations - 1084 (as of July 2017)

Mechanical ventilation guided by esophageal pressure in acute lung injury.
Talmor D, Sarge T, Malhotra A, O'Donnell CR, Ritz R, Lisbon A, Novack V, Loring SH.
N Engl J Med. 2008 Nov 13;359(20):2095-104.

Rationale for inclusion: Strong early study on measurement of transpulmonary pressures to guide PEEP.

Citations - 599 (as of July 2017)

Ventilation strategy using low tidal volumes, recruitment maneuvers, and high positive end-expiratory pressure for acute lung injury and acute respiratory distress syndrome: a randomized controlled trial.
Meade MO, Cook DJ, Guyatt GH, Slutsky AS, Arabi YM, Cooper DJ, Davies AR, Hand LE, Zhou Q, Thabane L, Austin P, Lapinsky S, Baxter A, Russell J, Skrobik Y, Ronco JJ, Stewart TE; Lung Open Ventilation Study Investigators.
JAMA. 2008 Feb 13;299(6):637-45.

Rationale for inclusion: The study which sums up the open lung approach to date.

Citations - 988 (as of July 2017)

Lung recruitment in patients with the acute respiratory distress syndrome.
Gattinoni L, Caironi P, Cressoni M, Chiumello D, Ranieri VM, Quintel M, Russo S, Patroniti N, Cornejo R, Bugedo G.
N Engl J Med. 2006 Apr 27;354(17):1775-86.

Rationale for inclusion: This is the study where Gattinoni et al performed CTs on patients while recruiting the lungs at 5, 10  and 45 cm H2O.

Citations - 991 (as of July 2017)

The concept of "baby lung".
Gattinoni L, Pesenti A.
Intensive Care Med. 2005 Jun;31(6):776-84.

Rationale for inclusion: Early use of the term "baby lung" to describe the parts of the lung actually working in ARDS.

Citations - 478 (as of July 2017)

Low-dose inhaled nitric oxide in patients with acute lung injury: a randomized controlled trial.
Taylor RW, Zimmerman JL, Dellinger RP, Straube RC, Criner GJ, Davis K Jr, Kelly KM, Smith TC, Small RJ; Inhaled Nitric Oxide in ARDS Study Group.
JAMA. 2004 Apr 7;291(13):1603-9.

Rationale for inclusion: The beginning of the end for iNO studies - showed improvement in hypoxemia but not in mortality.

Citations - 431 (as of July 2017)

Effect of a protective-ventilation strategy on mortality in the acute respiratory distress syndrome.
Amato MB, Barbas CS, Medeiros DM, Magaldi RB, Schettino GP, Lorenzi-Filho G, Kairalla RA, Deheinzelin D, Munoz C, Oliveira R, Takagaki TY, Carvalho CR.
N Engl J Med. 1998 Feb 5;338(6):347-54.

Rationale for inclusion: ARDSNet precursor study on protective lung ventilation.

Citations - 3566 (as of July 2017)

Beneficial effects of the "open lung approach" with low distending pressures in acute respiratory distress syndrome. A prospective randomized study on mechanical ventilation.
Amato MB, Barbas CS, Medeiros DM, Schettino Gde P, Lorenzi Filho G, Kairalla RA, Deheinzelin D, Morais C, Fernandes Ede O, Takagaki TY, et al.
Am J Respir Crit Care Med. 1995 Dec;152(6 Pt 1):1835-46.

Rationale for inclusion: Early mention of open lung hypothesis.

Citations - 689 (as of July 2017)

Effects of positive end-expiratory pressure on regional distribution of tidal volume and recruitment in adult respiratory distress syndrome.
Gattinoni L, Pelosi P, Crotti S, Valenza F.
Am J Respir Crit Care Med. 1995 Jun;151(6):1807-14.

Rationale for inclusion: Study demonstrating the effects of PEEP on lung recruitment using CT imaging.

Citations - 589 (as of July 2017)

Inhaled nitric oxide for the adult respiratory distress syndrome.
Rossaint R, Falke KJ, López F, Slama K, Pison U, Zapol WM.
N Engl J Med. 1993 Feb 11;328(6):399-405.

Rationale for inclusion: The best early study on inhaled nitric oxide; one that kicked off 20 years of research on iNO.

Citations - 1940 (as of July 2017)

Low mortality associated with low volume pressure limited ventilation with permissive hypercapnia in severe adult respiratory distress syndrome.
Hickling KG, Henderson SJ, Jackson R.
Intensive Care Med. 1990;16(6):372-7.

Rationale for inclusion: The earliest ARDSNet precursor study.

Citations - 999 (as of July 2017)

The prone position in ARDS patients. A clinical study.
Langer M, Mascheroni D, Marcolin R, Gattinoni L.
Chest. 1988 Jul;94(1):103-7.

Rationale for inclusion: Very early paper on the use of prone positioning in ARDS.

Citations - 424 (as of July 2017)

Ventilation-perfusion distributions in the adult respiratory distress syndrome.
Dantzker DR, Brook CJ, Dehart P, Lynch JP, Weg JG.
Am Rev Respir Dis. 1979 Nov;120(5):1039-52.

Rationale for inclusion: First demonstration of hypoxemia in ARDS as being due to VQ mismatch using inspired gases

Citations - 416 (as of July 2017)

Acute respiratory distress in adults.
Ashbaugh DG, Bigelow DB, Petty TL, Levine BE.
Lancet. 1967 Aug 12;2(7511):319-23.

Rationale for inclusion: Historical value - very early description of ARDS.

Citations - 3807 (as of July 2017)

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