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Respiratory - COPD and Pulm HTN

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Chronic obstructive pulmonary disease phenotypes: the future of COPD.
Han MK, Agusti A, Calverley PM, Celli BR, Criner G, Curtis JL, Fabbri LM, Goldin JG, Jones PW, Macnee W, Make BJ, Rabe KF, Rennard SI, Sciurba FC, Silverman EK, Vestbo J, Washko GR, Wouters EF, Martinez FJ.
Am J Respir Crit Care Med. 2010 Sep 1;182(5):598-604.

Rationale for inclusion: Excellent description of the different phenotypes of COPD.

Citations - 812 (as of July 2017)

Oral or IV prednisolone in the treatment of COPD exacerbations: a randomized, controlled, double-blind study.
de Jong YP, Uil SM, Grotjohan HP, Postma DS, Kerstjens HA, van den Berg JW.
Chest. 2007 Dec;132(6):1741-7.

Rationale for inclusion: This study defines the role of steroids during a COPD exacerbation.

Citations - 123 (as of July 2017)

A comparison of continuous intravenous epoprostenol (prostacyclin) with conventional therapy for primary pulmonary hypertension.
Barst RJ, Rubin LJ, Long WA, McGoon MD, Rich S, Badesch DB, Groves BM, Tapson VF, Bourge RC, Brundage BH, Koerner SK, Langleben D, Keller CA, Murali S, Uretsky BF, Clayton LM, Jöbsis MM, Blackburn SD, Shortino D, Crow JW; Primary Pulmonary Hypertension Study Group.
N Engl J Med. 1996 Feb 1;334(5):296-301.

Rationale for inclusion: This study introduces Prostacyclin for pulm HTN treatment.

Citations - 2618 (as of July 2017)

Noninvasive ventilation for acute exacerbations of chronic obstructive pulmonary disease.
Brochard L, Mancebo J, Wysocki M, Lofaso F, Conti G, Rauss A, Simonneau G, Benito S, Gasparetto A, Lemaire F, et al.
N Engl J Med. 1995 Sep 28;333(13):817-22.

Rationale for inclusion: Well referenced NEJM article on non-invasive ventilation for COPD.

Citations - 2177 (as of July 2017)

Antibiotic therapy in exacerbations of chronic obstructive pulmonary disease.
Anthonisen NR, Manfreda J, Warren CP, Hershfield ES, Harding GK, Nelson NA.
Ann Intern Med. 1987 Feb;106(2):196-204.

Rationale for inclusion: Highly referenced study describing Abx during COPD exacerbations.

Citations - 2634 (as of July 2017)

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