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Burn Injuries

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Pathophysiologic response to severe burn injury.
Jeschke MG, Chinkes DL, Finnerty CC, Kulp G, Suman OE, Norbury WB, Branski LK, Gauglitz GG, Mlcak RP, Herndon DN.
Ann Surg. 2008 Sep;248(3):387-401.

Rationale for inclusion: Burn patients show many markers of a hyper-inflammatory state.

Citations  - To review the number of citations for this landmark paper, visit Google Scholar.

Reversal of catabolism by beta-blockade after severe burns.
Herndon DN, Hart DW, Wolf SE, Chinkes DL, Wolfe RR.
N Engl J Med. 2001 Oct 25;345(17):1223-9.

Rationale for inclusion: Describes use of propranolol in children with burn injuries to attenuate hyper-metabolism and reverse muscle-protein catabolism.

Citations  - To review the number of citations for this landmark paper, visit Google Scholar.

Association of hyperglycemia with increased mortality after severe burn injury.
Gore DC, Chinkes D, Heggers J, Herndon DN, Wolf SE, Desai M.
J Trauma. 2001 Sep;51(3):540-4.

Rationale for inclusion: Poor glucose control in pediatric burn patients is associated with poor outcomes including skin graft take, bacteremia, and mortality.

Citations  - To review the number of citations for this landmark paper, visit Google Scholar.

Objective estimates of the probability of death from burn injuries.
Ryan CM, Schoenfeld DA, Thorpe WP, Sheridan RL, Cassem EH, Tompkins RG.
N Engl J Med. 1998 Feb 5;338(6):362-6.

Rationale for inclusion: Describes 3 risk factors (age greater than 60 years, more than 40 percent of body-surface area burned, and inhalation injury) to help predict risk of mortality after burns.

Citations  - To review the number of citations for this landmark paper, visit Google Scholar.

Use of an acellular allograft dermal matrix (AlloDerm) in the management of full-thickness burns.
Wainwright DJ.
Burns. 1995 Jun;21(4):243-8.

Rationale for inclusion: Describes use of human allograft skin for treatment of a full-thickness burn injury.

Citations  - To review the number of citations for this landmark paper, visit Google Scholar.

Permanent coverage of large burn wounds with autologous cultured human epithelium.
Gallico GG 3rd, O'Connor NE, Compton CC, Kehinde O, Green H.
N Engl J Med. 1984 Aug 16;311(7):448-51.

Rationale for inclusion: Well-cited, use of cultured epithelium to cover burn wounds with results similar to split thickness skin grafting.

Citations  - To review the number of citations for this landmark paper, visit Google Scholar.

Successful use of a physiologically acceptable artificial skin in the treatment of extensive burn injury.
Burke JF, Yannas IV, Quinby WC Jr, Bondoc CC, Jung WK.
Ann Surg. 1981 Oct;194(4):413-28.

Rationale for inclusion: Describes use of an artificial skin substitute for grafting to burn wounds.

Citations  - To review the number of citations for this landmark paper, visit Google Scholar.

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