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Burn Injuries

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Pathophysiologic response to severe burn injury.
Jeschke MG, Chinkes DL, Finnerty CC, Kulp G, Suman OE, Norbury WB, Branski LK, Gauglitz GG, Mlcak RP, Herndon DN.
Ann Surg. 2008 Sep;248(3):387-401.

Rationale for inclusion: Burn patients show many markers of a hyper-inflammatory state.

Citations - 191 (as of July 2017)

Reversal of catabolism by beta-blockade after severe burns.
Herndon DN, Hart DW, Wolf SE, Chinkes DL, Wolfe RR.
N Engl J Med. 2001 Oct 25;345(17):1223-9.

Rationale for inclusion: Describes use of propranolol in children with burn injuries to attenuate hyper-metabolism and reverse muscle-protein catabolism.

Citations - 467 (as of July 2017)

Association of hyperglycemia with increased mortality after severe burn injury.
Gore DC, Chinkes D, Heggers J, Herndon DN, Wolf SE, Desai M.
J Trauma. 2001 Sep;51(3):540-4.

Rationale for inclusion: Poor glucose control in pediatric burn patients is associated with poor outcomes including skin graft take, bacteremia, and mortality.

Citations - 476 (as of July 2017)

Objective estimates of the probability of death from burn injuries.
Ryan CM, Schoenfeld DA, Thorpe WP, Sheridan RL, Cassem EH, Tompkins RG.
N Engl J Med. 1998 Feb 5;338(6):362-6.

Rationale for inclusion: Describes 3 risk factors (age greater than 60 years, more than 40 percent of body-surface area burned, and inhalation injury) to help predict risk of mortality after burns.

Citations - 626 (as of July 2017)

Use of an acellular allograft dermal matrix (AlloDerm) in the management of full-thickness burns.
Wainwright DJ.
Burns. 1995 Jun;21(4):243-8.

Rationale for inclusion: Describes use of human allograft skin for treatment of a full-thickness burn injury.

Citations - 849 (as of July 2017)

Permanent coverage of large burn wounds with autologous cultured human epithelium.
Gallico GG 3rd, O'Connor NE, Compton CC, Kehinde O, Green H.
N Engl J Med. 1984 Aug 16;311(7):448-51.

Rationale for inclusion: Well-cited, use of cultured epithelium to cover burn wounds with results similar to split thickness skin grafting.

Citations - 1300 (as of July 2017)

Successful use of a physiologically acceptable artificial skin in the treatment of extensive burn injury.
Burke JF, Yannas IV, Quinby WC Jr, Bondoc CC, Jung WK.
Ann Surg. 1981 Oct;194(4):413-28.

Rationale for inclusion: Describes use of an artificial skin substitute for grafting to burn wounds.

Citations - 1141 (as of July 2017)

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