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EAST/AAST/AAST-AMC: SCC Review Series - Surgical Infections I - #9

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07/31/2025

Join Dr. Erika Bisgaard with the Expert Guest Dr. Scott Brakenridge, and Fellow Guest Dr. Erin White. This is the nineth episode of the Surgical Critical Care Review Series. This is a unique collaborative initiative between EAST and AAST. During this episode we will be discussing early management of septic shock, surviving sepsis campaign, Ventilator associated Pneumonia, C. Diff colitis and Necrotizing soft Tissue infections.
 
Content preparation: Dr. Erika Bisgaard & Dr. Mohammed Bawazeer
Content reviewer: Dr. Alex Brito
Moderator: Dr. Erika Bisgaard
Expert Guest: Dr. Scott Brakenridge
Fellow Guest: Dr. Erin White

Topics covered in this episode:

  • Sepsis, septic shock and Surviving sepsis guidelines
  • VAP and pulmonary infections
  • C diff colitis 
  • Necrotizing soft tissue infections 

Supplemental Material: 
Septic Shock

  • Caironi P, Tognoni G, Masson S, et al. Albumin replacement in patients with severe sepsis or septic shock. N Engl J Med. 2014;370(15):1412-1421. doi:10.1056/NEJMoa1305727 
  • Evans L, Rhodes A, Alhazzani W, et al. Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021. Intensive Care Med. 2021;47(11):1181-1247. doi:10.1007/s00134-021-06506-y
  • Fujii T, Luethi N, Young PJ, et al. Effect of vitamin C, hydrocortisone, and thiamine vs hydrocortisone alone on time alive and free of vasopressor support among patients with septic shock: the VITAMINS randomized clinical trial. JAMA. 2020;323(5):423-431. doi:10.1001/jama.2019.22176 [PMID: 31950979]

 Bacterial Infections 

  • Johnson S, Lavergne V, Skinner AM, et al. Clinical practice guideline by the Infectious Diseases Society of America (IDSA) and Society for Healthcare Epidemiology of America (SHEA): 2021 focused update guidelines on management of Clostridioides difficile infection in adults. Clin Infect Dis. 2021;73(5):755-757. doi:10.1093/cid/ciab718 
  • Tamma PD, Aitken SL, Bonomo RA, Mathers AJ, van Duin D, Clancy CJ. Infectious Diseases Society of America 2022 guidance on the treatment of extended-spectrum β-lactamase producing Enterobacterales (ESBL-E), carbapenem-Resistant Enterobacterales (CRE), and Pseudomonas aeruginosa with difficult-to-treat resistance (DTR-P. aeruginosa). Clin Infect Dis. 2022;75(2):187-212. doi:10.1093/cid/ciac268 
  • Yahav D, Franceschini E, Koppel F, et al. Seven versus 14 days of antibiotic therapy for uncomplicated gram-negative bacteremia: a noninferiority randomized controlled trial. Clin Infect Dis. 2019;69(7):1091-1098. doi:10.1093/cid/ciy1054
  • Oksi J, Anttila VJ, Mattila E. Treatment of Clostridioides (Clostridium) difficile infection. Ann Med. 2020;52(1-2):12-20. doi:10.1080/07853890.2019.1701703 [PMID: 31801387] • Wilcox MH, Gerding DN, Poxton IR, et al. Bezlotoxumab for prevention of recurrent Clostridium difficile infection. N Engl J Med. 2017;376(4):305-317. doi:10.1056/NEJMoa1602615 [PMID: 28121498]
  • Mazuski JE, Tessier JM, May AK, et al. The Surgical Infection Society revised guidelines on the management of intra-abdominal infection. Surg Infect (Larchmt). 2017;18(1):1-76. doi:10.1089/sur.2016.261 [PMID: 28085573]
  • Sawyer RG, Claridge JA, Nathens AB, et al. Trial of short-course antimicrobial therapy for intraabdominal infection. N Engl J Med. 2015;372(21):1996-2005. doi:10.1056/NEJMoa1411162 [PMID: 25992746]