EAST Registry-Based Randomized Controlled Trial (RRCT) Award Recipient - Dr. Christopher Guidry
Friday, November 7, 2025
The Study of Trauma Outcomes with Prophylaxis for Ventilator-Associated Pneumonia (STOP-VAP) RRCT.
Dr. Guidry will employ TQIP data to conduct a pragmatic multi-center registry-based cluster-randomized crossover superiority trial. Titled Study of Trauma Outcomes with Prophylaxis for Ventilator-Associated Pneumonia (STOP-VAP), the proposal includes two aims:
- Confirm the findings of the PROPHY-VAP trial and determine the efficacy of a single dose of prophylactic ceftriaxone given at reducing VAP-associated mortality in a general population of trauma patients who are intubated prior to or upon arrival
- Determine the impact of other commonly prescribed prophylactic antibiotics on both VAP rates and inpatient mortality in a general population of trauma patients who are intubated prior to or upon arrival.
This EAST funding mechanism is designed to support an RRCT that addresses a research gap identified in CNTR's National Trauma Research Action Plan.
Christopher Guidry, MD, FACS
Dr. Guidry is an associate professor in the Acute Care Surgery division of the University of Kansas Medical Center’s Department of Surgery. He completed his residency training at the University of Virginia where he also completed a research fellowship in surgical infectious disease. He completed his fellowship in Surgical Critical Care and Acute Care Surgery at Vanderbilt University Medical Center. He has been at the University of Kansas since 2019.
Dr. Guidry’s research focuses on antimicrobial stewardship and outcomes in trauma, emergency general surgery and surgical critical care including pragmatic clinical trials. He currently serves as the Director of Clinical Research for the Department of Surgery. Clinically Dr. Guidry practices the full spectrum of acute care surgery.