Coagulopathy of Trauma
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- Forgot calcium? Admission ionized-calcium in two civilian randomized controlled trials of prehospital plasma for traumatic hemorrhagic shock
- Moore HB, Tessmer MT, Moore EE, Sperry JL, Cohen MJ, Chapman MP, Pusateri AE, Guyette FX, Brown JB, Neal MD, Zuckerbraun B, Sauaia A.
- J Trauma Acute Care Surg. 2020 May;88(5):588-596.
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Rationale for inclusion: Prehospital plasma administration in the PAMPer and COMBAT trials was associated with hypocalcemia and predictive of lower survival and massive transfusion.
Citations - To review the number of citations for this landmark paper, visit Google Scholar.
- The role of four-factor prothrombin complex concentrate in coagulopathy of trauma: A propensity matched analysis.
- Jehan F, Aziz H, O'Keeffe T, Khan M, Zakaria ER, Hamidi M, Zeeshan M, Kulvatunyou N, Joseph B.
- J Trauma Acute Care Surg. 2018 Jul;85(1):18-24.
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Rationale for inclusion: Four factor PCC along with FFP was superior to FFP alone for the reversal of the coagulapathy of trauma.
Citations - To review the number of citations for this landmark paper, visit Google Scholar.
- Effect of treatment delay on the effectiveness and safety of antifibrinolytics in acute severe haemorrhage: a meta-analysis of individual patient-level data from 40?138 bleeding patients.
- Gayet-Ageron A, Prieto-Merino D, Ker K, Shakur H, Ageron FX, Roberts I; Antifibrinolytic Trials Collaboration.
- Lancet. 2018 Jan 13;391(10116):125-132.
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Rationale for inclusion: A meta-analysis of 2 randomized trials analyzing transexamic acid for acute severe bleeding. Survival benefit decreased 10% for every 15 minute TXA administration delay.
Citations - To review the number of citations for this landmark paper, visit Google Scholar.
- Persistent Fibrinolysis Shutdown Is Associated with Increased Mortality in Severely Injured Trauma Patients.
- Meizoso JP, Karcutskie CA, Ray JJ, Namias N, Schulman CI, Proctor KG.
- J Am Coll Surg. 2017 Apr;224(4):575-582.
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Rationale for inclusion: TEG was performed upon ICU admission in 181 trauma patients to find that persistent fibrinolsysis shutdown was associated with late mortality.
Citations - To review the number of citations for this landmark paper, visit Google Scholar.
- Tranexamic acid use in severely injured civilian patients and the effects on outcomes: a prospective cohort study.
- Cole E, Davenport R, Willett K, Brohi K.
- Ann Surg. 2015 Feb;261(2):390-4.
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Rationale for inclusion: Prospective study of TXA, use was associated with reduction in organ failure and all-cause mortality.
Citations - To review the number of citations for this landmark paper, visit Google Scholar.
- Hemostatic resuscitation is neither hemostatic nor resuscitative in trauma hemorrhage.
- Khan S, Brohi K, Chana M, Raza I, Stanworth S, Gaarder C, Davenport R; International Trauma Research Network (INTRN).
- J Trauma Acute Care Surg. 2014 Mar;76(3):561-7; discussion 567-8.
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Rationale for inclusion: For patients with ongoing bleeding, resuscitation directed by ROTEM did not achieve correction of hypo-perfusion or coagulopathy.
Citations - To review the number of citations for this landmark paper, visit Google Scholar.
- TEG-guided resuscitation is superior to standardized MTP resuscitation in massively transfused penetrating trauma patients.
- Tapia NM, Chang A, Norman M, Welsh F, Scott B, Wall MJ Jr, Mattox KL, Suliburk J.
- J Trauma Acute Care Surg. 2013 Feb;74(2):378-85; discussion 385-6.
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Rationale for inclusion: Comparison of standard MTP to TEG-directed resuscitation; TEG resuscitation patients had improved mortality in a subset of patients: patients with penetrating mechanism receiving more than 10U PRBCs.
Citations - To review the number of citations for this landmark paper, visit Google Scholar.
- The incidence and magnitude of fibrinolytic activation in trauma patients.
- Raza I, Davenport R, Rourke C, Platton S, Manson J, Spoors C, Khan S, De'Ath HD, Allard S, Hart DP, Pasi KJ, Hunt BJ, Stanworth S, MacCallum PK, Brohi K.
- J Thromb Haemost. 2013 Feb;11(2):307-14.
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Rationale for inclusion: Magnitude of fibronlytic activation correlates with clinical outcome in trauma patients, by thromboelastometry.
Citations - To review the number of citations for this landmark paper, visit Google Scholar.
- Admission rapid thrombelastography can replace conventional coagulation tests in the emergency department: experience with 1974 consecutive trauma patients.
- Holcomb JB, Minei KM, Scerbo ML, Radwan ZA, Wade CE, Kozar RA, Gill BS, Albarado R, McNutt MK, Khan S, Adams PR, McCarthy JJ, Cotton BA.
- Ann Surg. 2012 Sep;256(3):476-86.
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Rationale for inclusion: TEG at the time of admission showed better discrimination than conventional coagulation tests when predicting need for massive transfusion.
Citations - To review the number of citations for this landmark paper, visit Google Scholar.
- Early platelet dysfunction: an unrecognized role in the acute coagulopathy of trauma.
- Wohlauer MV, Moore EE, Thomas S, Sauaia A, Evans E, Harr J, Silliman CC, Ploplis V, Castellino FJ, Walsh M.
- J Am Coll Surg. 2012 May;214(5):739-46.
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Rationale for inclusion: Shows platelet dysfunction in trauma patients (compared with healthy volunteers) as seen in thromboelastography.
Citations - To review the number of citations for this landmark paper, visit Google Scholar.
- Functional definition and characterization of acute traumatic coagulopathy.
- Davenport R, Manson J, De'Ath H, Platton S, Coates A, Allard S, Hart D, Pearse R, Pasi KJ, MacCallum P, Stanworth S, Brohi K.
- Crit Care Med. 2011 Dec;39(12):2652-8.
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Rationale for inclusion: Use of ROTEM for point of care diagnosis of early coagulopathy.
Citations - To review the number of citations for this landmark paper, visit Google Scholar.
- The importance of early treatment with tranexamic acid in bleeding trauma patients: an exploratory analysis of the CRASH-2 randomised controlled trial.
- CRASH-2 collaborators, Roberts I, Shakur H, Afolabi A, Brohi K, Coats T, Dewan Y, Gando S, Guyatt G, Hunt BJ, Morales C, Perel P, Prieto-Merino D, Woolley T.
- Lancet. 2011 Mar 26;377(9771):1096-101, 1101.e1-2.
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Rationale for inclusion: Further analysis of the CRASH-2 trial data to explain the effect of TXA on bleeding deaths.
Citations - To review the number of citations for this landmark paper, visit Google Scholar.
- Primary fibrinolysis is integral in the pathogenesis of the acute coagulopathy of trauma.
- Kashuk JL, Moore EE, Sawyer M, Wohlauer M, Pezold M, Barnett C, Biffl WL, Burlew CC, Johnson JL, Sauaia A.
- Ann Surg. 2010 Sep;252(3):434-42; discussion 443-4.
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Rationale for inclusion: Identification of primary fibrinolysis by TEG is associated with death.
Citations - To review the number of citations for this landmark paper, visit Google Scholar.
- Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomised, placebo-controlled trial.
- CRASH-2 trial collaborators, Shakur H, Roberts I, Bautista R, Caballero J, Coats T, Dewan Y, El-Sayed H, Gogichaishvili T, Gupta S, Herrera J, Hunt B, Iribhogbe P, Izurieta M, Khamis H, Komolafe E, Marrero MA, Mejía-Mantilla J, Miranda J, Morales C, Olaomi O, Olldashi F, Perel P, Peto R, Ramana PV, Ravi RR, Yutthakasemsunt S.
- Lancet. 2010 Jul 3;376(9734):23-32.
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Rationale for inclusion: The CRASH-2 trial. Randomized use of TXA to placebo, showing decreased risk of death from bleeding in TXA group.
Citations - To review the number of citations for this landmark paper, visit Google Scholar.
- Goal-directed coagulation management of major trauma patients using thromboelastometry (ROTEM)-guided administration of fibrinogen concentrate and prothrombin complex concentrate.
- Schöchl H, Nienaber U, Hofer G, Voelckel W, Jambor C, Scharbert G, Kozek-Langenecker S, Solomon C.
- Crit Care. 2010;14(2):R55.
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Rationale for inclusion: Describes use of thromboelastometry to guide hemostatic therapy.
Citations - To review the number of citations for this landmark paper, visit Google Scholar.
- Evaluation of rotation thrombelastography for the diagnosis of hyperfibrinolysis in trauma patients.
- Levrat A, Gros A, Rugeri L, Inaba K, Floccard B, Negrier C, David JS.
- Br J Anaesth. 2008 Jun;100(6):792-7.
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Rationale for inclusion: Describes use of ROTEM to detect hyperfibrinolysis.
Citations - To review the number of citations for this landmark paper, visit Google Scholar.
- Acute coagulopathy of trauma: hypoperfusion induces systemic anticoagulation and hyperfibrinolysis.
- Brohi K, Cohen MJ, Ganter MT, Schultz MJ, Levi M, Mackersie RC, Pittet JF.
- J Trauma. 2008 May;64(5):1211-7; discussion 1217.
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Rationale for inclusion: Study examining blood drawn from trauma patients. Acute coagulopathy of trauma is associated with systemic hypoperfusion and is characterized by anticoagulation and hyperfibrinolysis.
Citations - To review the number of citations for this landmark paper, visit Google Scholar.
- Acute traumatic coagulopathy: initiated by hypoperfusion: modulated through the protein C pathway?
- Brohi K, Cohen MJ, Ganter MT, Matthay MA, Mackersie RC, Pittet JF.
- Ann Surg. 2007 May;245(5):812-8.
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Rationale for inclusion: Study of early coagulation labs predicting mortality in trauma.
Citations - To review the number of citations for this landmark paper, visit Google Scholar.
- Early coagulopathy in multiple injury: an analysis from the German Trauma Registry on 8724 patients.
- Maegele M, Lefering R, Yucel N, Tjardes T, Rixen D, Paffrath T, Simanski C, Neugebauer E, Bouillon B; AG Polytrauma of the German Trauma Society (DGU).
- Injury. 2007 Mar;38(3):298-304.
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Rationale for inclusion: Early coagulopathy is associated with need for increased fluids, multi-organ failure, and in-hospital mortality.
Citations - To review the number of citations for this landmark paper, visit Google Scholar.
- Diagnosis of early coagulation abnormalities in trauma patients by rotation thrombelastography.
- Rugeri L, Levrat A, David JS, Delecroix E, Floccard B, Gros A, Allaouchiche B, Negrier C.
- J Thromb Haemost. 2007 Feb;5(2):289-95.
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Rationale for inclusion: Description of the use of ROTEM for point of care detection of coagulation abnormalities in trauma patients.
Citations - To review the number of citations for this landmark paper, visit Google Scholar.
- Early coagulopathy predicts mortality in trauma.
- MacLeod JB, Lynn M, McKenney MG, Cohn SM, Murtha M.
- J Trauma. 2003 Jul;55(1):39-44.
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Rationale for inclusion: Abnormal coagulation labs are independent predictors of mortality in trauma.
Citations - To review the number of citations for this landmark paper, visit Google Scholar.
- Acute traumatic coagulopathy.
- Brohi K, Singh J, Heron M, Coats T.
- J Trauma. 2003 Jun;54(6):1127-30.
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Rationale for inclusion: Study showing high mortality in patients with coagulopathy.
Citations - To review the number of citations for this landmark paper, visit Google Scholar.
- Predicting life-threatening coagulopathy in the massively transfused trauma patient: hypothermia and acidoses revisited.
- Cosgriff N, Moore EE, Sauaia A, Kenny-Moynihan M, Burch JM, Galloway B.
- J Trauma. 1997 May;42(5):857-61; discussion 861-2.
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Rationale for inclusion: Prospective analysis of 58 patients who had a massive transfusion. Post-injury life-threatening coagulopathy in the seriously injured requiring massive transfusion is predicted by persistent hypothermia and progressive metabolic acidosis.
Citations - To review the number of citations for this landmark paper, visit Google Scholar.