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[beta]-BLOCKERS IN SEPSIS: REEXAMINING THE EVIDENCE
Published on Feb 1, 2009 from Shock
Sepsis remains the leading cause for noncardiac intensive care unit deaths in the United States. Despite recent advances in the treatment of this devastating condition, mortality and morbidity remain unacceptably high. Sepsis is characterized by a mu…
Rifle Classification for Predicting in-Hospital Mortality in Critically Ill Sepsis Patients
Published on Feb 1, 2009 from Shock
Severe sepsis and septic shock, often complicated by acute kidney injury (AKI), are the most common causes of mortality in noncoronary intensive care units (ICUs). This study investigates the outcomes of critically ill patients with sepsis and elucid…
Cardioprotection By Hydrogen Sulfide: Suspended Animation, Inflammation, and Apoptosis
Published on Feb 1, 2009 from Shock
No abstract available
Histological and Histochemical Methods: Theory and Practice, 4Th Edition
Published on Oct 1, 2008 from Shock
No abstract available
Janeway's Immunobiology, 7Th Edition
Published on Jun 1, 2008 from Shock
No abstract available
BERBERINE INHIBITS CYTOSOLIC PHOSPHOLIPASE A2 AND PROTECTS AGAINST LPS-INDUCED LUNG INJURY AND LETHALITY INDEPENDENT OF THE [alpha]2-ADRENERGIC RECEPTOR IN MICE
Published on May 1, 2008 from Shock
Acute lung injury is still a significant clinical problem having a high mortality rate despite significant advances in antimicrobial therapy and supportive care made in the past few years. Our previous study demonstrated that berberine (Ber) remarkab…
Hexosamine Biosynthesis and Protein O-Glycosylation: the First Line of Defense Against Stress, Ischemia, and Trauma
Published on Apr 1, 2008 from Shock
An early and rapid response to severe injury or trauma is the development of hyperglycemia, which has long been thought to be an essential survival response by providing fuel for vital organ systems and facilitating mobilization of interstitial fluid…
CYTOKINE-INDUCED EPITHELIAL PERMEABILITY CHANGES ARE REGULATED BY THE ACTIVATION OF THE p38 MITOGEN-ACTIVATED PROTEIN KINASE PATHWAY IN CULTURED CACO-2 CELLS
Published on Apr 1, 2008 from Shock
Increased intestinal/epithelial permeability in sepsis and endotoxemia has been noted to be induced by proinflammatory cytokines such as interferon-[gamma], TNF-[alpha], and IL-1[beta]. The p38 mitogen-activated protein kinase (MAPK) signaling pathwa…
Role of Toll-Like Receptors in the Development of Sepsis
Published on Mar 1, 2008 from Shock
The outcome of sepsis and septic shock has not significantly improved in recent decades despite the development of numerous drugs and supportive care therapies. To reduce sepsis-related mortality, a better understanding of molecular mechanism(s) asso…
Prognostic Value of Mortality in Emergency Department Sepsis Score, Procalcitonin, and C-Reactive Protein in Patients With Sepsis At the Emergency Department
Published on Mar 1, 2008 from Shock
The prognostic value of procalcitonin (PCT) in patients with sepsis at the emergency department (ED) has not been evaluated. We conducted a prospective observational study to compare the prognostic value of PCT on sepsis and compared with a validated…
Thermal Injury Elevates the Inflammatory Monocyte Subpopulation in Multiple Compartments
Published on Dec 1, 2007 from Shock
Recent publications have demonstrated that human resident and inflammatory monocyte (IM) subpopulations have equivalents in rodents. The effect of thermal injury upon these subpopulations has not been studied. Mice were given a scald burn and killed …
Single Bolus Injection of Bilirubin Improves the Clinical Outcome in A Mouse Model of Endotoxemia
Published on Nov 1, 2007 from Shock
Increasing serum levels of biliverdin and bilirubin was shown to be beneficial in settings of inflammation. Bilirubin was shown to be protective in LPS-induced lung injury in rats; however, the exact mechanism remains elusive. Here, we investigated w…
Stem Cell Mechanisms and Paracrine Effects: Potential in Cardiac Surgery
Published on Oct 1, 2007 from Shock
Heart disease remains the leading cause of death in the industrialized world. Stem cell therapy is a promising treatment modality for injured cardiac tissue. A novel mechanism for this cardioprotection may include paracrine actions. Cardiac surgery r…
Antisepsis, Disinfection, and Sterilization: Types, Action, and Resistance
Published on Sep 1, 2007 from Shock
No abstract available
Effects of Cd14-159 C/T Polymorphism on Cd14 Expression and the Balance Between Proinflammatory and Anti-Inflammatory Cytokines in Whole Blood Culture
Published on Aug 1, 2007 from Shock
CD14 is an important receptor of innate immunity. When CD14 is anchored by ligands to LPS, peptidoglycans, or lipoteichoic acid, it can result in either proinflammatory or anti-inflammatory responses. To determine whether CD14-159 C/T polymorphism is…
Research and Applications in Bacteriocins
Published on Aug 1, 2007 from Shock
No abstract available
Colon Ascendens Stent Peritonitis-A Model of Sepsis Adopted To the Rat: Physiological, Microcirculatory and Laboratory Changes
Published on Jul 1, 2007 from Shock
The colon ascendens stent peritonitis (CASP) procedure creates an intestinal leakage of feces, resulting in diffuse peritonitis and polymicrobial sepsis. Mouse models of CASP have been used to study sepsis experimentally. The aim of the present study…
Fluid Resuscitation in Severe Sepsis and Septic Shock: Albumin, Hydroxyethyl Starch, Gelatin or Ringer's Lactate-Does It Really Make A Difference?
Published on May 1, 2007 from Shock
The aim of this study was to investigate whether the type of i.v. fluid administered has an impact on outcome in an animal model of septic shock. The study included 28 anesthetized, invasively monitored, mechanically ventilated female sheep (29.5 +/-…
Dynamic Near-Infrared Spectroscopy Measurements in Patients With Severe Sepsis
Published on Apr 1, 2007 from Shock
This study evaluated near-infrared spectroscopy (NIRS)-derived measurements in hemodynamically stable patients with severe sepsis, as compared with similar measurements in healthy age-matched volunteers. Prospective, preliminary, observational study …
High Passage Number of Stem Cells Adversely Affects Stem Cell Activation and Myocardial Protection
Published on Dec 1, 2006 from Shock
Progenitor cell plasticity enhances positive remodeling of damaged tissue. We and others have previously shown that progenitor cells may limit apoptosis and modulate inflammation in part by the production of growth factors. However, recent studies su…

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