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Mof, Mods, and Sirs: What Is in A Name or An Acronym?
Published on Nov 1, 2006 from Shock
The most prominent contributions to multiple organ failure, multiple organ dysfunction syndrome, and systemic inflammatory response syndrome are described in this article. However, it is quite possible that there are others that have been missed. The…
Endothelium-Derived Microparticles Induce Endothelial Dysfunction and Acute Lung Injury
Published on Nov 1, 2006 from Shock
Acute lung injury (ALI) carries a high mortality in critically ill patients. Recent reports correlate elevated concentrations of endothelium-derived microparticles (EMPs) with diseases of endothelial dysfunction. Many of these diseases have ALI seque…
Emerging Paradigm: Toll-Like Receptor 4-Sentinel for the Detection of Tissue Damage
Published on Nov 1, 2006 from Shock
The systemic inflammatory response syndrome initiated by infection shares many features in common with the trauma-induced systemic response. The toll-like receptors (TLRs) stand at the interface of innate immune activation in the settings of both inf…
Vasoactive Drug Support in Septic Shock
Published on Nov 1, 2006 from Shock
No abstract available
Principles and Practice of Mechanical Ventilation, 2Nd Edition
Published on Oct 1, 2006 from Shock
No abstract available
Biomarkers of Acute Renal Injury and Renal Failure
Published on Sep 1, 2006 from Shock
Acute renal failure (ARF) is a frequent problem in the intensive care unit and is associated with a high mortality. Early recognition could help clinical management, but current indices lack sufficient predictive value for ARF. Therefore, there might…
Hmgb1 Signals Through Toll-Like Receptor (Tlr) 4 and Tlr2
Published on Aug 1, 2006 from Shock
In response to bacterial endotoxin (e.g., LPS) or endogenous proinflammatory cytokines (e.g., TNF and IL-1[beta]), innate immune cells release HMGB1, a late cytokine mediator of lethal endotoxemia and sepsis. The delayed kinetics of HMGB1 release mak…
The Cellular, Metabolic, and Systemic Consequences of Aggressive Fluid Resuscitation Strategies
Published on Aug 1, 2006 from Shock
Increasing evidence has demonstrated that aggressive crystalloid-based resuscitation strategies are associated with cardiac and pulmonary complications, gastrointestinal dysmotility, coagulation disturbances, and immunological and inflammatory mediat…
Effects of Dexamethasone on Macrophage Migration Inhibitory Factor Production in Sepsis
Published on Aug 1, 2006 from Shock
Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine that plays a major role in the pathogenesis of sepsis. Some studies have indicated that glucocorticoids increase MIF production in physiological conditions. The goal of this s…

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