Active Multicenter Trials - Currently Enrolling Centers

These EAST Multicenter Trials are current active and enrolling centers.  These studies are in the development, enrollment, and/or publication process.

2022 EAST Multicenter Trials

• Prospective Observational Trial Examining Nationwide Trends of Aggressive Resuscitation Protocols for Catastrophic Brain Injuries

2021 EAST Multicenter Trials

• Prospective study of Mean Arterial Blood Pressure Augmentation in the Treatment of Spinal Cord Injuries (MAP study): An EAST Multicenter Trial Proposal

• Outcomes Among Trauma Patients with Duodenal Leak Following Primary vs Complex Repair of Duodenal Injuries: An Eastern Association for the Surgery of Trauma Multicenter Trial

• Development and Validation of a Prehospital Triage Model for the Severely Injured Trauma Patient

• Breaking Old Dogma: Continuation of Enteral Feeds up to the Time of Tracheostomy and PEG Placement

• Intravascular access in hypotensive trauma patients: an Eastern Association for the Surgery of Trauma multicenter prospective observational trial using trauma video review

• Wound Management in Emergency Colorectal Surgery: To Close or Not to Close?

• Radiographic Evaluation of Delayed Solid Organ Complications (REDSOC) Study

• Social Determinants of Acute Abdomen Outcomes

• Contemporary Management of Right Upper Quadrant Gunshot Wounds

2020 EAST Multicenter Trials

• Cognitive Outcomes and NeuroStimulants among the Cerebrally Injured & Obtunded in the United States: The CONSCIOUS Study

• Impact of Coronavirus Disease 2019 on Trauma Center Volume and Resources: An EAST MCT

• Surgical Critical Care During COVID-19 Pandemic

• Intermediate Health and Social Outcomes following participation in Hospital Based Violence Intervention

• Prospective, multi-center, randomized, parallel-control, superiority, pragmatic study comparing administration of clotting factors concentrates with a standard massive hemorrhage protocol in severely bleeding trauma patients

• Prospective comparison of a short versus long chest tube water seal trial for traumatic pneumothorax

• Rates of Surgical Superficial Site Infections with Closure of Damage Control Laparotomy Incisions with Wicks/Incisional Wound Vacs

• Operative Versus Non-Operative Management for Appendicitis with Abscess or Phlegmon: An EAST Prospective Randomized Multicenter Trial

2019 EAST Multicenter Trials

• Brain vs. Bone: Does fracture fixation technique influence outcomes in patients with traumatic brain injury (TBI)?

• Prospective Multicenter Derivation and Validation of a NECROtizing Soft tissue Infection Score (NECROSIS)

2018 EAST Multicenter Trial

• A Multi-Institutional Cluster Randomized Trial Comparing Standard vs. Extended Venothromboembolic Prophylaxis After Major Trauma

• The Time Has Come To Question the ABCs Priorities of Trauma: Circulation First a Multicenter Prospective observational trial

2016 EAST Multicenter Trials

• Use of Surgical Fixation for Chest Wall Stabilization in Severe Traumatic Rib Fractures

• Mortality Analysis of Trauma Patients Repatriated to Non-Trauma Managed Care Institutions